Panama is the Americas' most underrated hub: a skyline that rivals Miami, a 300-year-old colonial quarter, the engineering marvel of the Canal, and — within an hour or two — rainforest, Caribbean islands, and Pacific beaches. It's also the region's best-connected hub, with Copa Airlines flying direct from a dozen US cities.
Panama City alone deserves two or three days: the Canal at Miraflores Locks, the rooftop bars and plazas of Casco Viejo (the UNESCO-listed old town), and the Biomuseo. Then choose your escape: the San Blas islands (the Guna people's picture-perfect cays), Bocas del Toro (Caribbean island life), or Boquete (coffee highlands and cloud forest).
The country uses the US dollar, drives on the right, and has excellent infrastructure — it's the easiest 'real Latin America' trip in the region.
Panama suits city-plus-nature travelers, canal enthusiasts, island hoppers, and anyone routing through on Copa (the stopover program makes adding 2–3 days nearly free). Dry season is December–April on the Pacific side.